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leprae. Anin silicostudy was done to grasp the molecular interactions involving DNA gyrase and WQ compounds. WQ-3334 and WQ-3810 have been shown to acquire larger inhibitory activity againstM. lepraeDNA gyrase than others. Also, Investigation employing quinolone-resistantM. lepraeDNA gyrases confirmed that WQ-3334 had larger inhibitory activity tha